The ATF6-Met[67]Val Substitution Is Associated With Increased Plasma Cholesterol Levels

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.

OBJECTIVE Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes. We used a 2-stage design to investigate whether ATF6 polymorphisms are associated with lipids in subjects at increased risk for cardiovascular disease (CVD). METHODS AND RESULTS In stage 1, 13 tag-SNPs were tested for association ...

National Cholesterol Awareness Month The ATF6-Met[67]Val Substitution Is Associated With Increased Plasma Cholesterol Levels

Increased Circulating miR-10a Levels Associated with Multiple Sclerosis

Background: Multiple sclerosis (MS) is an autoimmune disease that causes chronic inflammation of the central nervous system. MicroRNAs (miRNAs) are small non-coding RNAs 19–24 nucleotides long, which are differentially expressed in different tissues. The role of miRNAs in MS remains unclear. We assessed miR-10a transcript levels in MS patients during recurrence and two months after relapse. Ma...

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

BACKGROUND Irisin is a hormone released mainly from skeletal muscle after exercise which increases adipose tissue energy expenditure. Adipocytes can also release irisin after exercise, acting as a local adipokine to induce white adipose tissue to take on a brown adipose tissue-like phenotype, suggesting that irisin and its receptor may represent a novel molecular target for the treatment of obe...

Premature myocardial infarction is strongly associated with increased levels of remnant cholesterol.

BACKGROUND Remnant cholesterol has been defined as the cholesterol present in triglyceride-rich remnant lipoproteins. Elevated levels of remnant cholesterol have been associated with increased cardiovascular risk. Acute myocardial infarction (AMI) in very young individuals (≤40 years) represents a rare disease with a typical risk factor profile and a lipid phenotype that is characterized by a p...